Animal toxins, pharmacological opportunities against brain ischemia?
Keywords:
Isquemia, Receptor NMDA, Toxinas, Citotoxicidad, Tratamiento, Excitotoxicidad, Glutamato, FarmacológicoAbstract
Cerebrovascular diseases (CVD) comprise a group of disorders of the cerebral vasculature that decrease blood flow in the brain with temporary or permanent, generalized or focal involvement, with no apparent cause other than vascular origin. This review addresses a type of cerebrovascular accident - ischemic (CVA) - which is defined as the death of an area of brain tissue as a consequence of an insufficient supply of blood and oxygen to the brain due to a blocked artery. Stroke is one of the main causes of death from chronic diseases around the world, and the second cause of death in Colombia (1). The objective is to present how peptide toxins of arachnid origin, specifically from the Phoneutria boliviensis species, could represent an alternative treatment thanks to their interesting potential in pharmacological development, since it is known that animal toxins act on specific receptors in the nervous system (SN).
Downloads
References
World Health Organization. (2015, 13 octubre). ¿Qué son las enfermedades cardiovasculares? Organización Mundial de la Salud. https://www.who.int/cardiovascular_diseases/about_cvd/es/ [Accessed: 21-abr-2021].
Rabelo Padua, G., & Díaz Piñera, W. J. (2012). Enfermedades no transmisibles. Tendencias actuales. Revista Cubana de Salud y Trabajo, 13(2), 50-54.
Celestino Cuadrado, A. (2018). Nuevas dianas terapéuticas en el tratamiento de la isquemia cerebral.
Puentes Madera, I. C. (2014). Epidemiología de las enfermedades cerebrovasculares de origen extracraneal. Revista Cubana de Angiología y Cirugía Vascular, 15(2), 66-74.
Vyklicky, V., Korinek, M., Smejkalova, T., Balik, A., Krausova, B., Kaniakova, M., ... & Horak, M. (2014). Structure, function, and pharmacology of NMDA receptor channels. Physiological research, 63.
Mansbach, R. A., Travers, T., McMahon, B. H., Fair, J. M., & Gnanakaran, S. (2019). Snails in silico: A review of computational studies on the conopeptides. Marine drugs, 17(3), 145..
Tseng, W. P., & Lin-Shiau, S. Y. (2003). Activation of NMDA receptor partly involved in β-bungarotoxin-induced neurotoxicity in cultured primary neurons. Neurochemistry international, 42(4), 333-344.
“Modern Text Book of Zoology: Invertebrates - Prof. R.L.Kotpal - Google Libros.” [Online]. Available: https://books.google.es/books?hl=es&lr=&id=JuuWlZ7Llb8C&oi=fnd&pg=PA1&dq=Kotpal+R.+Modern+Text+Book+of+Zoology:+Invertebrates.+India:+Rastogi+Publications%3B+2012.+883+p.+&ots=h_UalCNlZj&sig=S_Aa4_cq157cH-avS7JrRYHZirQ#v=onepage&q=Kotpal R. Modern Text Book of Zoology%3A Invertebrates. India%3A Rastogi Publications%3B 2012. 883 p.&f=false. [Accessed: 01-Mar-2020].
C. M. Whittington and K. Belov, “Platypus venom: A review,” Australian Mammalogy, vol. 29, no. 1. CSIRO, pp. 57–62, 2007, doi: 10.1071/AM07006.
Holford, M., Daly, M., King, G. F. & Norton, R. S. Venoms to the rescue: insights into the evolutionary biology of venoms are leading to therapeutic advances. Science 361, 842–844 (2018).
W. Wüster, “Book Review: The Venomous Reptiles of the Western Hemisphere,” Trans. R. Soc. Trop. Med. Hyg., vol. 99, pp. 476–477, 2005, doi: 10.1016/j.trstmh.2004.12.001.
J. Andrés Pereáñez Jiménez and L. Johana Vargas Muñoz, “Toxinas de serpientes con alto potencial terapéutico y su uso en la biomedicina,” 2008.
R. Otero, R. G. Osorio, R. Valderrama, and C. A. Giraldo, “Efectos farmacológicos y enzimáticos de los venenos de serpientes de Antioquia y Chocó (Colombia),” Toxicon, vol. 30, no. 5–6, pp. 611–620, May 1992, doi: 10.1016/0041-0101(92)90855-Y
E. Ortiz-Prado, C. Molina, D. Ramírez, E. Espín, and D. Fierro, “Perspectivas actuales sobre el uso terapéutico del veneno de serpientes.”
“Perspectivas actuales sobre el uso terapéutico del veneno de serpientes - PDF Free Download.” [Online]. Available: https://docplayer.es/52226318-Perspectivas-actuales-sobre-el-uso-terapeutico-del-veneno-de-serpientes.html. [Accessed: 01-Mar-2020].
F. E. Russell, “Snake venom immunology: Historical and practical considerations,” Toxin Rev., vol. 7, no. 1, pp. 1–82, (1988), doi: 10.3109/15569548809059725.
Bogin O. Venom. Toxins and Toxin Mimetics as Potential Drugs. Modulator. (2005) 9–13.
Le Du M-H, Servent D, Zinn-Justin S, Ménez A, Bourgoin M, Gilquin B, et al. Motions and structural variability within toxins: Implication for their use as scaffolds for protein engineering. Protein Sci. 2003;12:266–77.
Vetter, I. et al. Venomics: a new paradigm for natural products- based drug discovery. Amino Acids 40, 15–28 (2011).
Dutertre, S. et al. in Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics (ed. King, G. F.) 80–96 (Royal Society of Chemistry, 2015).
Muttenthaler M, King GF, Adams DJ, Alewood PF. Trends in peptide drug discovery. Nat Rev Drug Discov. 2021 Feb 3. doi: 10.1038/s41573-020-00135-8. Epub ahead of print. PMID: 33536635.
Estrada-Gomez, L. J. V. Muñoz, P. Lanchero, and C. S. Latorre, “Partial characterization of venom from the Colombian spider Phoneutria boliviensis (Aranae:Ctenidae),” Toxins (Basel)., vol. 7, no. 8, pp. 2872–2887, Jul. 2015, doi: 10.3390/toxins7082872.
Reyes-Guzman EA, Vega-Castro N, Reyes-Montaño EA, Recio-Pinto E. Antagonistic action on NMDA/GluN2B mediated currents of two peptides that were conantokin-G structure-based designed. BMC Neurosci. 2017;18:1–13.
Carvajal J and Reyes-Guzman EA. (2020). Tesis de pregrado. In silico analysis of the interactión of peptides derived from the Ctenitoxin-Pb48 and Ctenitoxin-Pb53 toxins of the Colombian spider Phoneutria boliviensis with the NMDA receptor.
Bermúdez S and Reyes-Guzmán EA. (2021). Tesis de pregrado. “Evaluación del efecto citotóxico de los péptidos pb48a y pb53a sobre la línea celular HEK-293”.
Fosgerau K and Hoffmann T. (2015). Peptide therapeutics: current status and future directions. Drug Discovery Today. Volume 20, Number 1. 122-128.
Downloads
Published
-
Abstract128
-
PDF (Español (España))86
How to Cite
Issue
Section
License
Copyright (c) 2021 Yair Santiago Bermúdez Urrego, Edwin Alfredo ReyesGuzmán, María Elisa Forero Vivas
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.