Efectos del etanol en la expresión génica de ɑ-sinucleína en células cancerígenas.

Authors

  • Breyner Joel Quiñones Castro
  • Mauricio Rey Buitrago Universidad Antonio Nariño

Keywords:

A-sinucleína, Alcoholismo, Expresión diferencial

Abstract

The chronic use of alcohol has been associated with significant changes in the expression of α-synuclein, altering the reward system and generating neuronal and mitochondrial damage. There are very few treatments for this disease and the results are modest, so your study is necessary for the development of new therapies. The objective of this study was to determine the effect of low doses of ethanol in cancer cells with different dosage schedules and to determine the rate of expression of the gene α-synuclein. It shows that there is a decrease in the expression of α-synuclein in the treatments with ethanol.

Downloads

Download data is not yet available.

References

Bohn, M. J., Babor, T. F., & Kranzler, H. R. (1990). The Alcohol Use Disorders Identification Test ( AUDIT ): Validation of a Screening Instrument for Use in Medical Settings * ’ UMEROUS assessment methods been designed.

Janeczek, P., & Lewohl, J. M. (2013). The role of α-synuclein in the pathophysiology of alcoholism. Neurochemistry International, 63(3), 154–162. https://doi.org/10.1016/j.neuint.2013.06.007

Lundgaard, I., Wang, W., Eberhardt, A., Vinitsky, H. S., Reeves, B. C., Peng, S., … Nedergaard, M. (2018). Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. Scientific Reports, 8(1), 1–16. https://doi.org/10.1038/s41598-018-20424-y

McCarter, K. D., Li, C., Jiang, Z., Lu, W., Smith, H. C., Xu, G., ... Sun, H. (2017). Effectof Low-Dose Alcohol Consumption on Inflammation Following Transient FocalCerebral Ischemia in Rats. Scientific Reports, 7(1), 1–9.https://doi.org/10.1038/s41598-017-12720-w

Ministerio de Salud y Proteccion Social. (2013). ESTRATEGIA NACIONAL DE RESPUESTA INTEGRAL FRENTE AL CONSUMO DE. Colombia.

Momen-Heravi, F., Saha, B., Kodys, K., Catalano, D., Satishchandran, A., & Szabo, G. (2015). Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis. Journal of Translational Medicine, 13(1), 1–13. https://doi.org/10.1186/s12967-015-0623-9

Pelucchi, C., Tramacere, I., Boffetta, P., Negri, E., & Vecchia, C. La. (2011). Alcohol consumption and cancer risk. Nutrition and Cancer, 63(7), 983–990. https://doi.org/10.1080/01635581.2011.596642

World Health Organization. (1994). Glosario de términos de alcohol y drogas. Ministerio de Salud y Consumo, (Madrid).

Downloads

Published

2020-03-20
Metrics
Views/Downloads
  • Abstract
    145
  • PDF (Español)
    179

How to Cite

Quiñones Castro, B. J., & Rey Buitrago, M. (2020). Efectos del etanol en la expresión génica de ɑ-sinucleína en células cancerígenas. REVISTA SAYWA, 1(1). Retrieved from https://revistas.uan.edu.co/index.php/saywa/article/view/673

Issue

Vol. 1 No. 1 (2019)

Section

Ciencia Aplicada

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Metrics

Most read articles by the same author(s)