Promising discovery of three plants with anticancer activity

Authors

  • Karen A. Reyes Álvarez Universidad Colegio Mayor de Cundinamarca
  • Erika J. Lozano Aguilar Universidad Colegio Mayor de Cundinamarca
  • Harold Gómez Estrada Universidad de Cartagena
  • Nelitza Linárez Alvarez Universidad Antonio Nariño
  • Orlando A. Torres Garcia Universidad Antonio Nariño
  • Ana L. Muñoz Ramírez Universidad Antonio Nariño

Keywords:

Extractos herbales, Cáncer, Osteosarcoma, Medicina natural

Abstract

Osteosarcoma is the most common type of bone cancer that affects children, adolescents and young adults. It is a disease characterized by having an aggressive treatment and in general a poor prognosis. Its treatment includes radiotherapy, chemotherapy and surgery, that although they seek to improve the overall health of the patient, can cause undesirable side effects in patients, and they do not reach 100% effectiveness. Therefore, it is necessary to search for new effective therapeutic alternatives that do not generate adverse effects and do not involve high medical expenses.

Natural medicine is a tool that favors the treatment of different types of cancer, since numerous studies show that plants have components that interfere in the survival and death of cancer cells. For this reason, the objective of this research was to determine the anticancer activity of three plants extracts found in the colombian Atlantic Coast, on two cell lines OSCA-8...

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References

ACCO (2018). Osteosarcoma. American Childhood Cancer Organization. Recuperado de: [https://www.acco.org/ bone-cancer/].

Alfranca, A., Martínez-Cruzado, L., Tornin, J., Abarrategi, A., Amaral, T., de Alava, E. y Rodríguez, R. (2015). Bone microenvironment signals in osteosarcoma development. Cellular and Molecular Life Sciences , 72 (16), pp. 3097-3113 [doi.org/10.1007/s00018-015-1918-y].

Bade, R., Chan, H. F. y Reynisson, J. (2010). Characteristics of known drug space. Natural products, their derivatives and synthetic drugs. European Journal of Medicinal Chemistry, 45 (12), pp. 5646-5652 [doi. org/10.1016/j.ejmech.2010.09.018].

Devlin, E. J., Denson, L. A. y Whitford, H. S. (2017). Cancer Treatment Side Effects: A Meta-analysis of the Relationship Between Response Expectancies and Experience. Journal of Pain and Symptom Management, 54 (2), pp. 245-258.e2 [doi.org/10.1016/j.jpainsymman.2017.03.017].

Escobar, L. M., Rivera, A. y Aristizábal, F. A. (2010). Estudio comparativo de los métodos de resazurina y MTT en estudios de citotoxicidad en líneas celulares tumorales humanas. Vitae, 17 (1), pp. 67-74. Recuperado de: [http://www.scielo.org.co/scielo.php?script=sci_arttextypid=S0121-4004201000 0100009].

Fryxell, P. A. (1845). Malvaceae. Flora de Veracruz, Vol. 13827, pp. 103-154. Disponibble en: [http://www1.inecol. edu.mx/publicaciones/resumeness/FLOVER/68-fryxell_I.pdf].

Leite, M. L., Da Cunha, N. B. y Costa, F. F. (2018). Antimicrobial peptides, nanotechnology, and natural metabolites as novel approaches for cancer treatment. Pharmacology and Therapeutics, 183, pp. 160-176 [doi. org/10.1016/j.pharmthera.2017.10.010].

López Roldán, P., Álvarez Gómez, S., y González Pulido, J. L. (2011). Actualización del osteosarcoma para el médico de familia. SEMERGEN - Medicina de Familia, 37 (1), pp. 22–29 [doi.org/10.1016/j.semerg.2010.06.008].

Matias, E. F. F., Alves, E. F., Silva, M. K. do N., Carvalho, V. R. de A., Coutinh, H. D. M. y da Costa, J. G. M. (2015). The genus Cordia: Botanists, ethno, chemical and pharmacological aspects. Brazilian Journal of Pharmacognosy, 25 (5), pp. 542–552 [doi.org/10.1016/j.bjp.2015.05.012].

Melo, J. I. M. de, y Sales, M. F. de. (2004). Heliotropium L. (Boraginaceae - Heliotropioideae) de Pernambuco, Nordeste do Brasil,. Rodriguésia, 55 (84), pp. 65–87. [doi.org/10.1590/2175-78602004558405].

Plummer, M., de Martel, C., Vignat, J., Ferlay, J., Bray, F. y Franceschi, S. (2016, September). Global burden of cancers attributable to infections in 2012: a synthetic analysis [doi.org/10.1016/S2214-109X(16)30143-7].

Popoca, J., Aguilar, A., Alonso, D. y Villarreal, M. L. (1998). Cytotoxic activity of selected plants used as antitumorals in Mexican traditional medicine. Journal of Ethnopharmacology, 59 (3), pp. 173-177 [doi.org/10.1016/ S0378-8741(97)00110-4].

Ranieri, G., Gadaleta, C. D., Patruno, R., Zizzo, N., Daidone, M. G., Hansson, M. G., … Ribatti, D. (2013). A model of study for human cancer: Spontaneous occurring tumors in dogs. Biological features and translation for new anticancer therapies. Critical Reviews in Oncology/Hematology, 88 (1), pp. 187–197 [doi.org/10.1016/j. critrevonc.2013.03.005].

Wang, Y., Deng, X., Yu, C., Zhao, G., Zhou, J., Zhang, G. y Zhang, Y. (2018). Synergistic inhibitory effects of capsaicin combined with cisplatin on human osteosarcoma in culture and in xenografts. Journal of Experimental y Clinical Cancer Research, 37 (1), p. 251 [doi.org/10.1186/s13046-018-0922-0].

Published

2020-03-20
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How to Cite

Reyes Álvarez, K. A. ., Lozano Aguilar, E. J. ., Gómez Estrada, H., Linárez Alvarez, N., Torres Garcia, O. A., & Muñoz Ramírez, A. L. (2020). Promising discovery of three plants with anticancer activity. REVISTA SAYWA, 1(1). Retrieved from https://revistas.uan.edu.co/index.php/saywa/article/view/675

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Ciencia Aplicada

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